Integration of Epstein-Barr Virus into Chromosome 6q15 of Burkitt Lymphoma Cell Line (Raji) Induces Loss of BACH2 Expression
نویسندگان
چکیده
منابع مشابه
Epstein-Barr virus and Burkitt lymphoma
In 1964, a new herpesvirus, Epstein-Barr virus (EBV), was discovered in cultured tumor cells derived from a Burkitt lymphoma (BL) biopsy taken from an African patient. This was a momentous event that reinvigorated research into viruses as a possible cause of human cancers. Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B cells, and that all cases of ...
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Background & Objectives: The Epstein-Barr Virus (EBV( is related with various diseases including infectious mononucleosis, Burkitt's lymphoma, Hodgkin's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoprolifrative disorders. The aim of this study was to characterize the association between EBV and Hodgkin's lymphoma through EBERs in situ hybridization (EBER-ISH) in Iranian pat...
متن کاملAzidothymidine inhibits NF-kappaB and induces Epstein-Barr virus gene expression in Burkitt lymphoma.
The antiviral compound azidothymidine (AZT), alone or in combination with other agents, induces apoptosis in early-passage, Epstein-Barr virus-positive Burkitt lymphoma (EBV+ BL) lines and has clinical activity in EBV+ BL. We report here a mechanism of AZT's antitumor activity. The nuclei of these cells contain activated nuclear factor-kappaB (NF-kappaB) subunits p50, c-Rel, RelB, and p52, but ...
متن کاملAzidothymidine inhibits NF- B and induces Epstein-Barr virus gene expression in Burkitt lymphoma
The antiviral compound azidothymidine (AZT), alone or in combination with other agents, induces apoptosis in earlypassage, Epstein-Barr virus–positive Burkitt lymphoma (EBV BL) lines and has clinical activity in EBV BL. We report here a mechanism of AZT’s antitumor activity. The nuclei of these cells contain activated nuclear factorB (NFB) subunits p50, c-Rel, RelB, and p52, but not p65. Treatm...
متن کاملBurkitt lymphoma and the discovery of Epstein-Barr virus.
The chance germinal encounter with the first lecture outside Africa on Burkitt lymphoma is described together with the hypothesis of a viral cause. Repeated virological investigations on lymphoma biopsies proved negative, leading to the idea that a latent virus might be activated if lymphoma cells could be cultured, although no human lymphoid cell had at that time ever been maintained in vitro....
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2004
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63184-7